Increased Concentration of Soluble CD40 Ligand in Preeclampsia
نویسندگان
چکیده
منابع مشابه
Soluble CD40 ligand in acute coronary syndromes.
BACKGROUND CD40 ligand is expressed on platelets and released from them on activation. We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the therapeutic effect of glycoprotein IIb/IIIa receptor inhibition in patients with acute coronary syndromes. METHODS Serum levels of soluble CD40 ligand were measured in 1088 patients with acute coronary syndr...
متن کاملIncreased concentrations of soluble CD40 ligand platelet in patients with primary antiphospholipidic syndrome.
OBJECTIVE To determine the concentrations of sCD40L in patients with PAPS, and establish its association with the number of thrombosis. PATIENTS AND METHODS We included patients with PAPS and healthy controls of the same age and sex. For analysis, patients with PAPS were divided into 2 groups: 1) patients with 1 thrombosis, and 2) patients with >1 thrombosis. Soluble CD40L concentrations were...
متن کاملIncreased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis.
CD40 ligand (CD40L) is expressed on activated CD4(+) T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage. We measured sCD40L in the plasma of either healthy subjects; patients with inflammatory disorders and low, normal, or high platelet count (reactive thrombocytosis); or patients with essential thr...
متن کاملSoluble CD40 Ligand in Aspirin-Treated Patients Undergoing Cardiac Catheterization
Plasma soluble CD40 ligand (sCD40L) is mainly generated by cleavage of CD40L from the surface of activated platelets, and therefore considered a platelet activation marker. Although the predictive value of sCD40L for ischemic events has been demonstrated in patients with acute coronary syndromes (ACS), studies on the association of sCD40L with cardiovascular outcomes in lower risk populations y...
متن کاملThe soluble CD40 ligand sCD154 in systemic lupus erythematosus.
We found that the plasma of patients with active systemic lupus erythematosus (SLE) could induce a human B-cell line (Ramos) to express high levels of immune accessory molecules that are commonly found on blood B cells of patients with active SLE. The ability of SLE plasma to induce such phenotypic changes could be abrogated by neutralizing antibodies specific for the CD40 ligand (CD154) but no...
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ژورنال
عنوان ژورنال: Clinical and Applied Thrombosis/Hemostasis
سال: 2007
ISSN: 1076-0296,1938-2723
DOI: 10.1177/1076029606299076